HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-2'-nitroacetophenone → 3-[4-(2-Nitro-phenyl)-oxazol-2-yl]-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-2'-nitroacetophenone | HCID 244025 | — |
| Reactant | Methyl 3-carbamoylpropanoate | HCID 12550576 | — |
| Reactant | 4-[4-(2-Nitro-phenyl)-oxazol-2-yl]-butyric acid methyl ester | HCID 59167791 | — |
| Product | 3-[4-(2-Nitro-phenyl)-oxazol-2-yl]-propionic acid methyl ester | HCID 59167749 | 36% |
Reaction Steps
Using a method similar to the procedure described for the preparation of 4-[4-(2-nitro-phenyl)-oxazol-2-yl]-butyric acid methyl ester; reaction of 2-bromo-2′-nitroacetophenone (15.43 g, 63.2 mmol) with succinamic acid methyl ester (14.4 g, 110 mmol) gives 3-[4-(2-nitro-phenyl)-oxazol-2-yl]-propionic acid methyl ester (6.24 g, 36%). MS (ES): (M+1)+ 277.1 m/z.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552039B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-e24e28b6d505436faef2816a9f444562 |
| Source note | uspto-grants-2013_10 |