Boron tribromide → HCID 136400604, compound

Participants

Reaction Steps

Dissolve 5-[2-(2-methoxy-phenyl)-thiazol-4-yl]-pentanoic acid methyl ester (3.3 g, 10.8 mmol) in CH2Cl2 (30 mL) under nitrogen at room temperature. Add boron tribromide (1M in CH2Cl2, 27 mL) and stir at room temperature until the reaction is complete. Quench the mixture with methanol, add ice/water and extract with CH2Cl2. Dry the combined extracts over Na2SO4 and concentrate. Chromatograph the resulting residue over silica gel (EtOAc/CH2Cl2) to allow for isolation of 5-[2-(2-hydroxy-phenyl)-thiazol-4-yl]-pentanoic acid methyl ester (2.2 g, 70%). MS (ES): (M+1)+ 292.1 m/z.

Provenance & Evidence