Pyridine → 1-(2,4-dichloro-phenyl)-3-fluoro-propan-2-one O-methyl-oxime

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a stirred solution of 1-(2,4-dichloro-phenyl)-3-fluoro-propan-2-one (0.34 g; 1.5 mmol) in methanol (3 ml) was added pyridine (0.4 ml; 4.9 mmol) followed by a portionwise addition of methoxyamine hydrochloride (0.41 g; 4.9 mmol). The reaction mixture was stirred for 16 hours at 23° C. The mixture was washed with water (5 ml), the aqueous layer was extracted with dichloromethane (3×5 ml) and dried over sodium sulfate. The solvent was removed in vacuo to afford 0.40 g (100% of theory) of crude 1-(2,4-dichloro-phenyl)-3-fluoro-propan-2-one O-methyl-oxime (isomers E/Z) as a yellow oil.

Herkunft & Nachweise