HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxo-2-butenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoate | HCID 73856874 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxo-2-butenoic acid | HCID 73856873 | — |
Reaction Steps
To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoate (Step E) in abs ethanol at low temp, add aqueous sodium hydroxide, after an hour, concentrate and purify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552062B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-589b7dfe13e14e44b19ddf13ca38272f |
| Source note | uspto-grants-2013_10 |