Hydrochloric Acid → HCID 178424441, compound

Participants

Reaction Steps

To a mixture of 314 mg (purity: 96.0%; 1.83 mmol) of 4-hydroxy-3,6-dichloropyridazine and 828 mg (5.50 mmol) of 2-cyclopropyl-6-methylphenol were added tributylamine (2.76 g) and 334 mg (5.56 mmol) of 95% potassium hydroxide at room temperature. The resultant mixture was heated to 180° C. while stirring, and stirred at that temperature for 4 hours. Then, the resultant reaction mixture was cooled to room temperature, and a 1 N aqueous hydrochloric acid solution and methanol were added to the reaction mixture to obtain a uniform solution. The obtained solution was quantitatively determined by an HPLC internal standard analysis method, which showed that 288 mg of 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (yield: 57%) and 2.5 mg of 3-chloro-6-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (yield: 0.5%) were obtained.

Provenance & Evidence