Hydrochloric Acid → HCID 178424441, compound

Participants

Reaction Steps

To a mixture of 302 mg (purity: 100%; 1.83 mmol) of 4-hydroxy-3,6-dichloropyridazine and 826 mg (5.48 mmol) of 2-cyclopropyl-6-methylphenol were added 2-methyl-4-phenylbutanol (2.76 g) and 330 mg (5.60 mmol) of 95% potassium hydroxide at room temperature. The resultant mixture was heated to 180° C. while stirring, and stirred at that temperature for 4 hours. Then, the resultant reaction mixture was cooled to room temperature, and a 1 N aqueous hydrochloric acid solution and methanol were added to the reaction mixture to obtain a uniform solution. The obtained solution was quantitatively determined by an HPLC internal standard analysis method, which showed that 332 mg of 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (yield: 66%) and 3.6 mg of 3-chloro-6-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (yield: 0.7%) were obtained.

Provenance & Evidence