反应详情

温度

27.5 °C

Laquinimod (2.7 gm) was taken in ethanol (13 ml) and stirred at 25-30° C. followed by the addition of sodium hydroxide solution (0.33 gm of NaOH in 0.4 ml of water). The resulting solution was stirred for 15 minutes followed by filtration through hyflow bed and washing of the bed with ethanol (7 ml). The resulting clear solution was then stirred for 16 hours at 25-30° C. The separated solid was filtered, washed with chilled ethanol (2 ml) and then dried at 60-65° C. to yield 2.33 gin of laquinimod sodium as a white solid (HPLC Purity: 99.92%).

1. stirringThe resulting solution was stirred for 15 minutes
2. filtrationfollowed by filtration through hyflow bed
3. washwashing of the bed with ethanol (7 ml)
4. stirringThe resulting clear solution was then stirred for 16 hours at 25-30° C
5. filtrationThe separated solid was filtered
6. washwashed with chilled ethanol (2 ml)
7. customdried at 60-65° C.