HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → 4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | (4-{[(Oxan-2-yl)oxy]methyl}phenyl)methanol | HCID 67139706 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | 4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl acetate | HCID 68007957 | 92.9% |
Reaction Steps
Under a nitrogen atmosphere, a mixture of (4-((tetrahydro-2H-pyran-2-yloxy)methyl)phenyl)methanol (3.0 mmol), t-butanol (3.6 mmol), the zinc cluster obtained in the above-described Example 5 (0.0375 mmol), and diisopropyl ether (5.0 ml) was refluxed for 18 hours. As a result, 4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl acetate was obtained in a yield of 92.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552204B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-a827e590f89b49bfa3be32e99c973f13 |
| Source note | uspto-grants-2013_10 |