HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Benzoate → (S)-4-isopropyl-2-phenyloxazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Benzoate | HCID 7150 | — |
| Reactant | L-Valinol | HCID 640993 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | (S)-4-isopropyl-2-phenyloxazoline | HCID 10947327 | 84% |
Reaction Steps
Under a nitrogen atmosphere, a mixture of methyl benzoate (1.5 mmol), (S)-valinol (1.8 mmol), a zinc cluster Zn4O (OCOCF3)6 (0.0375 mmol), and chlorobenzene (2.5 ml) was refluxed for 12 hours. As a result, (S)-4-isopropyl-2-phenyloxazoline was obtained in a yield of 84%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552204B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-815567aaca864708a3729b756d493b17 |
| Source note | uspto-grants-2013_10 |