反应详情

The product of Step 1 (5.11 g, 26.0 mmol) was dissolved in MeOH (80 ml). Palladium on carbon (0.416 g, 0.391 mmol) was added, and the flask was fitted with a hydrogen balloon. The flask was evacuated and backfilled with hydrogen (3×) and stirred 15 h at room temperature. The reaction was then filtered through Celite and the celite was washed with EtOAc. The filtrate was concentrated in vacuo. Purification via silica gel flash chromatography (0-15% EtOAc:Hexanes) gave methyl(cis)-4-oxo-2-(propan-2-yl)cyclohexanecarboxylate (2.63 g, 51%) as a colorless oil.

1. customThe flask was evacuated
2. filtrationThe reaction was then filtered through Celite
3. washthe celite was washed with EtOAc
4. concentrationThe filtrate was concentrated in vacuo
5. customPurification via silica gel flash chromatography (0-15% EtOAc:Hexanes)