Decanal → HCID 24807657, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-leucine methyl ester hydrochloride (1 gm, 5.5 mmol), THF (20 mL), MgSO4 (1.12 gm, 9.35 mmol), decanal (2.06 mL, 11.0 mmol), Et3N (767 μL, 5.5 mmol), sodium borohydride (416 mg, 11.0 mmol), and methanol (25 mL) to give 11b (800 mg, 51%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.88-0.98 (9H, m), 1.2-1.37 (15H, m), 1.42-1.54 (4H, m), 1.71 (1H, heptet), 2.42-2.5 (1H, m), 2.53-2.6 (1H, m), 3.29 (1H, t, J=7.32 Hz), 3.74 (3H, s). ESI-MS: 308.1 (M+23).

Provenance & Evidence