Benzaldehyde → HCID 58996879, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-phenylalanine ethyl ester hydrochloride (2 gm, 8.7 mmol), THF (25 mL), MgSO4 (1.78 gm, 14.79 mmol), benzaldehyde (1.77 mL, 17.4 mmol), Et3N (1.21 mL, 8.7 mmol), sodium borohydride (658 mg, 17.4 mmol), and methanol (30 mL) to give 11c (1.5 gm, 61%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 1.19 (3H, t, J=7.08 Hz), 1.88-2.1 (1H, bs), 3.01 (2H, dd, J=0.97, 7.81 Hz), 3.56 (1H, t, J=6.83 Hz), 3.69 (1H, d, J=13.42 Hz), 3.85 (1H, d, J=13.18 Hz), 4.13 (2H, q, J=7.32 Hz), 7.18-7.22 (2H, m), 7.23-7.33 (8H, m). ESI-MS: 284.0 (M+1).

Provenance & Evidence