Triethylamine → HCID 24807836, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-leucine methyl ester hydrochloride (2 gm, 11.0 mmol), THF (30 mL), MgSO4 (2.24 gm, 18.7 mmol), 4-fluorobenzaldehyde (2.37 mL, 22.0 mmol), Et3N (1.53 mL, 11.0 mmol), sodium borohydride (833 mg, 22.0 mmol), and methanol (40 mL) to give 11e (1.3 gm, 47%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.84 (3H, d, J=6.59 Hz), 0.9 (3H, d, J=6.59 Hz), 1.47-1.58 (2H, m), 1.76 (1H, heptet), 3.3 (1H, t, J=7.32 Hz), 3.63 (1H, d, J=12.93 Hz), 3.72 (3H, s), 3.81 (1H, d, J=12.93 Hz), 6.99 (2H, t, J=8.78 Hz), 7.32 (2H, dd, J=5.37, 8.3 Hz). ESI-MS: 276.2 (M+23).

Provenance & Evidence