Sulfuric acid magnesium salt (1:1) → HCID 24807837, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using D-leucine methyl ester hydrochloride (2 gm, 11.0 mmol), THF (30 mL), MgSO4 (2.24 gm, 18.7 mmol), 4-fluorobenzaldehyde (2.37 mL, 22.0 mmol), Et3N (1.53 mL), sodium borohydride (833 mg, 22.0 mmol), and methanol (40 mL) to give 11f (1.72 gm, 62%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.84 (3H, d, J=6.59 Hz), 0.91 (3H, d, J=6.59 Hz), 1.4-1.52 (2H, m), 1.64-1.72 (1H, bs), 1.77 (1H, heptet), 3.27 (1H, t, J=7.41 Hz), 3.56 (1H, d, J=12.9 Hz), 3.72 (3H, s), 3.77 (1H, d, J=12.9 Hz), 6.99 (2H, t, J=8.78 Hz), 7.28 (2H, dd, J=5.49, 8.51 Hz). ESI-MS: 276.0 (M+23).

Provenance & Evidence