Acetaldehyde → HCID 24807658, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-phenylalanine ethyl ester hydrochloride (2 gm, 8.7 mmol), THF (25 mL), MgSO4 (1.77 gm, 14.79 mmol), acetaldehyde (983 μL, 17.4 mmol), Et3N (1.21 mL, 8.7 mmol), sodium borohydride (658 mg, 17.4 mmol), and methanol (30 mL) to give 11h (900 mg, 47%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 1.1 (3H, t, J=7.13 Hz), 1.15 (3H, t, J=7.13 Hz), 1.42-1.7 (1H, bs), 2.46-2.73 (2H, m), 2.96 (2H, dq, J=7.44, 13.42 Hz), 3.53 (1H, t, J=6.88 Hz), 4.1 (2H, q, J=7.13 Hz), 7.16-7.38 (5H, m). ESI-MS: 244.1 (M+23).

Provenance & Evidence