Butanal → HCID 12967662, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-leucine methyl ester hydrochloride (1.5 gm, 8.25 mmol), THF (25 mL), MgSO4 (1.68 gm, 14.02 mmol), butyraldehyde (1.45 mL, 16.5 mmol), Et3N (1.14 mL, 8.25 mmol), sodium borohydride (625 mg, 16.5 mmol), and methanol (25 mL) to give 11j (450 mg, 27%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.86-0.98 (9H, m), 1.24-1.52 (7H, m), 1.64-1.74 (1H, heptet), 2.4-2.48 (1H, m), 2.52-2.6 (1H, m), 3.27 (1H, t, J=7.33 Hz), 3.71 (3H, s). ESI-MS: 224.1 (M+23).

Provenance & Evidence