Triethylamine → HCID 24808002, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-leucine methyl ester hydrochloride (1.0 gm, 5.5 mmol), THF (25 mL), MgSO4 (1.12 gm, 9.35 mmol), biphenyl carboxaldehyde (2.0 g, 11.0 mmol), Et3N (767 μL, 5.5 mmol), sodium borohydride (417 mg, 11.0 mmol), and methanol (20 mL) to give 11k (750 mg, 44%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.86 (3H, d, J=6.59 Hz), 0.92 (3H d, J=6.59 Hz), 1.49 (2H, dt, J=3.17, 7.07 Hz), 1.7-1.76 (1H, bs), 1.8 (1H, heptet), 3.33 (1H, t, J=7.56 Hz), 3.65 (1H, d, J=12.93 Hz), 3.72 (3H, s), 3.85 (1H, d, J=13.18 Hz), 7.32 (1H, t, J=7.56 Hz), 7.38-7.42 (4H, m), 7.54 (2H, d, J=7.81 Hz), 7.58 (2H, d, J=7.32 Hz). ESI-MS: 312.4 (M+1).

Provenance & Evidence