Decanal → HCID 11034987, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-phenyl alanine ethyl ester hydrochloride (1.0 gm, 4.35 mmol), THF (20 mL), MgSO4 (522 mg, 4.35 mmol), decanal (817 μL, 4.35 mmol), Et3N (606 μL, 4.35 mmol), sodium borohydride (330 mg, 8.7 mmol), and methanol (20 mL) to give 11n (270 mg, 19%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.88 (3H, d, J=7.08 Hz), 1.14 (3H, t, J=7.32 Hz), 1.2-1.32 (14H, m), 1.34-1.5 (3H, m), 2.5-2.55 (1H, m), 2.52-2.6 (1H, m), 2.9 (1H, dd, J=7.56, 13.42 Hz), 2.97 (1H, dd, J=6.59, 13.42 Hz), 3.48 (1H, t, J=6.83 Hz), 4.08 (2H, q, J=7.32 Hz), 7.18 (2H, d, J=7.32 Hz), 7.22 (1H, d, J=0.73 Hz), 7.24-7.3 (2H, m). ESI-MS: 334.4 (M+1).

Provenance & Evidence