Furfural → HCID 68941260, compound

Participants

Reaction Steps

Synthesized according to the general procedure as described in Example 1a using L-isoleucine methyl ester hydrochloride (2.5 gm, 1 equiv), THF (30 mL), MgSO4 (2.8 gm, 1.7 equiv), 2-furaldehyde (2.27 mL, 2 equiv), and Et3N (1.91 mL, 1 equiv), sodium borohydride (1.04 gm, 2 equiv), and methanol (40 mL) to give 11p (2.2 gm, 71%) in FIG. 2. 1H NMR (500 MHz, CDCl3): δ 0.86-0.92 (6H, m), 1.16-1.26 (1H, m), 1.48-1.58 (1H, m), 1.68-1.74 (1H, m), 1.78-1.98 (1H, bs), 3.16 (1H, d, J=5.85 Hz), 3.67 (1H, d, J=14.15 Hz), 3.71 (3H, s), 3.82 (1H, d, J=14.4 Hz), 6.19 (1H, d, J=3.17 Hz), 6.32 (1H, d, J=2.68 Hz), 7.37 (1H, d, J=1.95 Hz). ESI-MS: 248.1 (M+23).

Provenance & Evidence