Dichloromethane → 3-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

HRID 1040302Notes

Reaction equation

HRID 1040302 reaction equation
[CH3:1][N:2]([CH3:16])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].[Cl:17]CCl>Cl.C(OC(C)C)(C)C>[ClH:17].[CH3:16][N:2]([CH3:1])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 64330913-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol

Product 1

HCID 231069343-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

Reagents, catalysts & solvents 1

HCID 21510344Isopropyl ether hydrochlorideSolvent

Procedure

To stirred solution of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (4 g, 0.02 mol) in dichloromethane (20 ml), isopropyl ether hydrochloride (6 ml) was added at ambient temperature and stirred for 30 minutes. Solvents were distilled off from the reaction mixture. To the residue isopropyl ether (8 ml) was added and stirred for 15 minutes. Solvent was distilled off from the mixture to give 4.3 g of the title compound.

Workup

  1. additionwas added at ambient temperature
  2. distillationSolvents were distilled off from the reaction mixture
  3. additionTo the residue isopropyl ether (8 ml) was added
  4. stirringstirred for 15 minutes
  5. distillationSolvent was distilled off from the mixture

Sources & evidence

ORD record
ord-d3d93c13df264a87a63513b0942b1daf
Source dataset
uspto-grants-2013_10
Patent number
US08552219B2

Reaction notes

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