HRID1040338

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4866632

9-aminobicyclo[3.3.1]nonane-9-carboxylic Acid

C10H17NO2

结构：COc1cccc(OC)c1-c1ccc(C(=O)O)nc1-c1ccc(Cl)c(OCCCN(C)C)c1

HCID66720875

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(OC)c1-c1ccc(C(=O)NC2(C(=O)O)C3CCCC2CCC3)nc1-c1ccc(Cl)c(OCCCN(C)C)c1.Cl

HCID66721144

未命名化合物

收率 77%

PROCEDURE

实验过程

According to the method described in example 1.8, starting from 400 mg (0.85 mmol) of 6-{4-chloro-3-[3-(dimethylamino)propoxy]phenyl}-5-(2,6-dimethoxyphenyl)pyridine-2-carboxylic acid and 218 mg (1.19 mmol) of 9-aminobicyclo[3.3.1]nonane-9-carboxylic acid and after reverse-phase purification and lyophilization, we obtain 220 mg of 9-({[6-{4-chloro-3-[3-(dimethylamino)propoxy]phenyl}-5-(2,6-dimethoxyphenyl)pyridin-2-yl]carbonyl}amino)bicyclo[3.3.1]nonane-9-carboxylic acid hydrochloride in the form of white powder.

WORKUP

后处理

customafter reverse-phase purification and lyophilization, we

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a615cda6f7e34b69b27b8598d81e5251
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08552201B2
来源说明: uspto-grants-2013_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[C:17]2[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:18]=2[O:25][CH3:26])=[CH:4][C:3]=1[O:27][CH2:28][CH2:29][CH2:30][N:31]([CH3:33])[CH3:32].[NH2:34][C:35]1([C:44]([OH:46])=[O:45])[CH:40]2[CH2:41][CH2:42][CH2:43][CH:36]1[CH2:37][CH2:38][CH2:39]2>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([NH:34][C:35]3([C:44]([OH:46])=[O:45])[CH:40]4[CH2:41][CH2:42][CH2:43][CH:36]3[CH2:37][CH2:38][CH2:39]4)=[O:15])[CH:11]=[CH:10][C:9]=2[C:17]2[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:18]=2[O:25][CH3:26])=[CH:4][C:3]=1[O:27][CH2:28][CH2:29][CH2:30][N:31]([CH3:33])[CH3:32]