Hydrochloric Acid → HCID 67106369, compound

Participants

Reaction Steps

To a solution of (1E,6E)-1-[2-bromo-4-(4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (35 mg, 0.063 mmol, synthesized in Example 126) in 1.0 mL of ethyl acetate was added 3M HCl (1.0 mL) at room temperature. After being stirred at room temperature overnight, the reaction mixture was concentrated in vacuo. The residue was treated with diethyl ether, and the resulting solid was collected by filtration. The solid was rinsed with ether, and dried under reduced pressure to obtain the title compound as a solid (28.0 mg, 84%).

Provenance & Evidence