5-Aminopyridine-2-carbonitrile → HCID 55295868, compound

Participants

Reaction Steps

To a solution of 5-amino-2-cyanopyridine (1.0 g, 8.06 mmol) in dry THF (50 mL) was added titanium(IV) isopropoxide (5.2 mL, 17.7 mmol). EtMgBr (3.0M in Et2O, 10.7 mL, 32.2 mmol) was then added dropwise. The reaction mixture was stirred for 23 h, then diluted with water (100 mL) and 1N HCl (5 mL), and stirred for 5 min. The mixture was filtered and the filtrate was concentrated in vacuo to afford 6-(1-amino-cyclopropyl)-pyridin-3-ylamine as brown oil (10 g) which was used without further purification.

Provenance & Evidence