HCID 178521699, compound → HCID 178507185, compound

HRID 1040443Notes

Reaction equation

HRID 1040443 reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][CH:17]=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:16]1[N:15]=[C:14]([C:11]2([NH2:10])[CH2:13][CH2:12]2)[NH:18][CH:17]=1

Participants

4

Reactant 1

HCID 178521699HCID 178521699, compound

Product 1

HCID 178507185HCID 178507185, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [1-(4H-[1,2,4]triazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (60 mg, 0.23 mmol) in MeOH (5 mL) was added 10% Pd/C (60 mg). The reaction mixture was stirred under H2 atmosphere (balloon) for 1.5 h. The reaction mixture was filtered through diatomaceous earth. The solvent was concentrated in vacuo and dried under high vacuum to afford 28 mg of the title compound, m/z 125.5 [M+1]+.

Workup

  1. filtrationThe reaction mixture was filtered through diatomaceous earth
  2. concentrationThe solvent was concentrated in vacuo
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-b1cbcd54f9224bd88a8376b29afa1e1f
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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