1-(5-Methylpyridin-2-yl)cyclopropan-1-amine → HCID 67390164, compound

HRID 1040445Notes

Reaction equation

HRID 1040445 reaction equation
[CH:1]1([C:4]2[O:5][CH:6]=[C:7]([C:9]3([NH2:12])[CH2:11][CH2:10]3)[N:8]=2)[CH2:3][CH2:2]1.CC1ON=C(C2(N)CC2)C=1.CC1C=CC(C2(N)CC2)=NC=1.C(OC(=O)NCC1C=NC(C2(N)CC2)=CC=1)(C)(C)C.CN(CC1C=CC(C2(N)CC2)=NC=1)C.[Si](OCC1C=CC(C2(N)CC2)=NC=1)(C(C)(C)C)(C)C.C([SiH2]OC(C)(C)C1C=CN=C(C2(N)CC2)C=1)(C)(C)C.BrC1C=CC(C2(N)CC2)=NC=1.IC1C=CN=C(C2(N)CC2)C=1.NC1(C2N=CC(N(C)C)=CC=2)CC1.CC1SC=C(C2(N)CC2)N=1>>[CH:1]([C:4]1[O:5][CH:6]=[C:7]([C:9]2([NH2:12])[CH2:10][CH2:11]2)[N:8]=1)([CH3:3])[CH3:2]

Participants

12

Reactant 11

HCID 552647461-(5-Methylpyridin-2-yl)cyclopropan-1-amineHCID 552980821-(2-Methyl-thiazol-4-yl)-cyclopropylamineHCID 573568181-(5-Bromopyridin-2-yl)cyclopropanamineHCID 59406983HCID 59406983, compoundHCID 67210921HCID 67210921, compoundHCID 673895656-(1-Aminocyclopropyl)-N,N-dimethyl-3-pyridinamineHCID 67390359HCID 67390359, compoundHCID 67390512HCID 67390512, compoundHCID 67390766HCID 67390766, compoundHCID 673908011,1-Dimethylethyl N-[[6-(1-aminocyclopropyl)-3-pyridinyl]methyl]carbamateHCID 131730896HCID 131730896, compound

Product 1

HCID 67390164HCID 67390164, compound

Procedure

1-(2-Cyclopropyloxazol-4-yl)cyclopropylamine; 1-(5-Methylisoxazol-3-yl)cyclopropylamine; 1-(5-Methylpyridin-2-yl)cyclopropylamine; [6-(1-Aminocyclopropyl)pyridin-3-ylmethyl]carbamic acid tert-butyl ester; 1-(5-Dimethylaminomethylpyridin-2-yl)cyclopropylamine; 1-[5-(tert-Butyldimethylsilanyloxymethyl)pyridin-2-yl]cyclopropylamine (Carbonitrile precursor was synthesized according to literature procedure: LecClerc et al. J. Het. Chem. 1993, 30, 631.); 1-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-cyclopropylamine (Carbonitrile precursor was synthesized according to literature procedure: LecClerc et al. J. Het. Chem. 1993, 30, 631.); 1-(5-Bromo-pyridin-2-yl)-cyclopropylamine; 1-(4-Iodo-pyridin-2-yl)-cyclopropylamine; [6-(1-Amino-cyclopropyl)-pyridin-3-yl]-dimethyl-amine; 1-(2-methyl-thiazol-4-yl)-cyclopropylamine:

Sources & evidence

ORD record
ord-37e9117733264f90995c90732539e9a9
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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