Diisopropylethylamine → HCID 67391472、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	1-{[(Benzyloxy)carbonyl]amino}cyclopropane-1-carboxylic acid	HCID 3589012	—
反応物	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
反応物	1-(4-Oxazolyl)cyclopropanamine	HCID 55285532	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	HCID 67391472	HCID 67391472	32.1%

反応手順

To a round bottom flask was added Z-1-aminocyclopropane-1-carboxylic acid (150 mg, 0.638 mmol) in DMF (10 ml), followed by the addition of Hunig's base (207 mg, 1.6 mmol) and HATU (270 mg, 0.71 mmol). The reaction mixture was stirred at room temperature for 15 min, followed by the addition of 1-Oxazol-4-yl-cyclopropylamine (200 mg, 1.6 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo. The residue was purified by prepHPLC to afford 70 mg of [1-(1-oxazol-4-yl-cyclopropylcarbamoyl)-cyclopropyl]-carbamic acid benzyl ester, m/z 343 [M+1]+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08552205B2
出典データセット	uspto-grants-2013_10
ORD ID	ord-3605e290fdad42349ab63b3a6f26d669
出典メモ	uspto-grants-2013_10