反应详情

A solution of Hydroxyimino-pyridin-2-yl-acetic acid methyl ester (2.0 g, 11.1 mmol) in ethanol (50 mL) was placed in a round bottom flask. The flask was evacuated under vacuum and filled with Ar2 three times. Then 200 mg of 10% Pd on Carbon was added in one portion. The flask was evacuated again under vacuum and filled with Hydrogen three times. The reaction was stirred at room temperature under a balloon containing H2 for 16 h. The mixture was filtered through a pad of celite and rinsed with DCM three times. The combined organics were concentrated down to give Amino-pyridin-2-yl-acetic acid methyl ester (1.8 g) as a yellow oil which was used immediately in next step without further purification, m/z 167.55 [M+1]+

1. customThe flask was evacuated under vacuum
2. additionfilled with Ar2 three times
3. additionThen 200 mg of 10% Pd on Carbon was added in one portion
4. customThe flask was evacuated again under vacuum
5. additionfilled with Hydrogen three times
6. additioncontaining H2 for 16 h
7. filtrationThe mixture was filtered through a pad of celite
8. washrinsed with DCM three times
9. concentrationThe combined organics were concentrated down