tert-Butanol → HCID 58430865, compound

Participants

Reaction Steps

1-Pyridin-2-yl-cyclobutanecarboxylic acid (2.0 g, 11.3 mmol) was combined with t-BuOH 50 mL), Et3N (1.78 mL, 12.4 mmol) and diphenylphosphoryl azide (2.7 mL, 12.4 mmol). The reaction was heated to reflux for 1.5 h. The t-BuOH was removed in vacuo to yield 7.0 g of crude (1-pyridin-2-yl-cyclobutyl)-carbamic acid tert-butyl ester as a pink-black oil. The crude product was used in subsequent reactions without further purification.

Provenance & Evidence