反应详情

温度

80 °C

A mixture of 0.50 g (1.6 mmol) of 2-tert-butoxycarbonylamino-4-1,2,3-triazol-2-yl-butyric acid methyl ester in 1.0 mL of MeOH and 3.0 mL (9.0 mmol) of 3M aq. NaOH is stirred at 80° C. for 60 min The mixture was cooled to rt and washed with EtOAc (1×10 mL). After adjusting the pH to 4 with 3M HCl, the mixture is extracted with EtOAc (3×) and the extracts are washed with brine, then dried with Na2SO4, filtered, and concentrated to provide 0.42 g (87%) of 2-tert-butoxycarbonylamino-4-1,2,3-triazol-2-yl-butyric acid as a white solid.

1. temperaturewas cooled to rt
2. washwashed with EtOAc (1×10 mL)
3. extractionthe mixture is extracted with EtOAc (3×)
4. washthe extracts are washed with brine
5. dry with materialdried with Na2SO4
6. filtrationfiltered
7. concentrationconcentrated