Hydrazine → HCID 178464920, compound

Participants

Reaction Steps

To a solution of 3-[(R)-1-((S)-2-{[(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-propionyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester (40 mg, 0.05 mmol) in ethanol (2 mL) was added hydrazine (8.5 μL, 0.26 mmol). The reaction mixture was stirred at room temperature for 1.5 h. The solvent was evaporated in vacuo, and the residue was purified using reverse phase HPLC to afford the title compound (27 mg, 71%) as a white solid, m/z 720.6 [M+1]+.

Provenance & Evidence