Ammonia → HCID 58431056, compound

Participants

Reaction Conditions

Reaction Steps

(R)-1-((S)-2-{[(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-propionyl)-piperidine-3-carboxylic acid ethyl ester was dissolved in 7N NH3 in MeOH (5 mL) and heated to 70° C. for 48 h. The volatiles were removed in vacuo and the crude residue was purified by reverse phase HPLC to afford 0.049 g of the title compound as a white foam, m/z 622.3 [M+1]+.

Provenance & Evidence