Hydrochloric Acid → HCID 67391000, compound

Participants

Reaction Conditions

Reaction Steps

To (1R,3R)-3-((S)-2-{[(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-propionylamino)-cyclopentanecarboxylic acid methyl ester (35.1 mg, 0.055 mmol) were added 1N HCl in 1,4-dioxane (1 mL, 1 mmol) and 1N HCl (0.5 mL, 0.5 mmol). The reaction tube was sealed and the reaction solution was stirred at 100° C. for 1 h. The reaction solution was then cooled to room temperature, filtered, and was purified by reverse phase HPLC to afford 21 mg of the title compound as a white solid, m/z 623.1 [M+1]+.

Provenance & Evidence