Trifluoroacetic acid → HCID 67389228, compound

Participants

Reaction Steps

4-(1-{[(R)-5-(4-Cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-cyclopropanecarbonyl)-piperazine-1,3-dicarboxylic acid di-tert-butyl ester (256 mg, 0.32 mmol) was dissolved in CH2Cl2 (2 mL) and TFA (2 mL) was added dropwise. After 16 h, the reaction was concentrated in vacuo. The crude orange oil was dissolved in DMSO (1.5 mL), purified via reverse phase HPLC to afford 64 mg of 1-(1-{[(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-cyclo-propanecarbonyl)-piperazine-2-carboxylic acid trifluoroacetic acid salt as a white solid.

Provenance & Evidence