Hydrochloric Acid → HCID 58431148, compound

Participants

Reaction Conditions

Reaction Steps

1N HCl in 1,4-dioxane (1 mL, 1 mmol) and 1N HCl (aq.) (0.5 mL, 0.5 mmol) were added to methyl (1S,3R)-3-({[1-({[(3R)-3-(4-cyanobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[1,2-a]imidazol-5-yl]carbonyl}amino)cyclopropyl]-carbonyl}amino)cyclopentanecarboxylate (35 mg, 0.054 mmol). The reaction tube was sealed and the reaction solution was stirred at 100° C. for 1 h. The reaction solution was then cooled to room temperature, filtered and purified via reverse phase HPLC. The title compound (23.1 mg) was isolated as a white solid, m/z 635.1 [M+1]+.

Provenance & Evidence