HCID 58431111, compound → HCID 42632961, compound

Participants

Reaction Steps

A solution of (R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid [1-(1-{6-[bis-(4-methoxy-benzyl)-amino]-pyridin-2-yl}-cyclopropylcarbamoyl)-cyclopropyl]-amide (80 mg, 0.084 mmol) in trifluoroacetic acid (2 mL) was stirred at room temperature for 4 h. The solvent was removed under a stream of N2 and the residue was partitioned between EtOAc (4 mL) and saturated aqueous NaHCO3 (4 mL). The layers were separated and the aqueous layer was further extracted with EtOAc (2×4 mL). The combined organics were evaporated in vacuo, and the residue was purified via reverse phase HPLC. The purified material was then passed through a basic amino group functionalized solid phase extraction cartridge to give 31 mg (51%) of the title compound as a white solid, m/z 715.0 [M+2]+.

Provenance & Evidence