Hydrochloric Acid → (S)-2-Amino-N-(1-pyrimidin-2-yl-cyclopropyl)-propionamide

Participants

Reaction Steps

[(S)-1-(1-Pyrimidin-2-yl-cyclopropylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (54 mg, 0.18 mmol) was dissolved in CH2Cl2 (1 mL). HCl solution (4M in 1,4-dioxane, 1.5 mL, 6.0 mmol) was added via in one portion via syringe and the reaction was allowed to stir for 1.5 h. Solvents were removed in vacuo yielding (S)-2-Amino-N-(1-pyrimidin-2-yl-cyclopropyl)-propionamide as a white powder, m/z 207.41 [M+1]+.

Provenance & Evidence