Dichloromethane → HCID 42635287, compound

Participants

Reaction Steps

(2-{1-[(1-{[(R)-5-(4-Cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl]-amino}-cyclopropanecarbonyl)-amino]-cyclopropyl}-pyridin-4-ylmethyl)-carbamic acid tert-butyl ester (45 mg, 0.06 mmol) was placed in RBF with CH2Cl2 and TFA was added. The reaction was diluted with 10 mL 10% MeOH/CH2Cl2 and washed with water (2×5 mL). The organic layer was separated, dried (MgSO4), and concentrated. Reverse Phase HPLC purification (30-100% CH3CN/H2O as gradient) yielded 66 mg of the title compound as a bis-TFA salt, m/z=669.5 [M+1]+.

Provenance & Evidence