참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Butynyl p-toluenesulfonate | HCID 272020 | — |
| 반응물 | (R)-2-methylpyrrolidine L-tartrate | HCID 11858493 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (R)-1-(But-3-yn-1-yl)-2-methylpyrrolidine | HCID 11367023 | — |
반응 단계
To a sealed flask was added 2-(R)-methylpyrrolidine L-tartrate (21.1 g, 90 mmol), 3-butynyl p-toluenesulfonate (15.7 mL, 89 mmol), potassium carbonate powder (18.5 g, 134 mmol) and CH3CN (160 mL). The resulting mixture was heated to 85° C. for 24 hours and the reaction was monitored by GC for the complete consumption of the tosylate. The reaction mixture was cooled to room temperature and filtered the wet cake was washed with CH3CN (40 mL). The combined filtrate was used in the next step without further processing.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07094790B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-aaf4f21a45734751b2c179840ecdc207 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
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