HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Bromide → 8-Ethyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine | HCID 57853872 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Ethyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine | HCID 67264412 | 86.2% |
Reaction Steps
To a solution of 6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine (0.07 g, 0.00039 mol) and N-ethyldiisopropylamine (0.066 g, 0.00047 mol) in DCM (4 mL) was added bromoethane (0.051 g, 0.00047 mol), stirred 20 h and evaporated to give 8-ethyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine (0.07 g) as an oil. MS (ESI+): 209 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552186B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-6b5f47c120614684a20afcee6116852d |
| Source note | uspto-grants-2013_10 |