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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1040941Generated: October 30, 2026

1-Acetoxy-2-bromoethane → acetic acid 2-(2-amino-6,7-dihydro-9H-5-thia-8-aza-benzocyclohepten-8-yl)-ethyl ester

https://huagongshe.com/reaction/1040941

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Acetoxy-2-bromoethaneHCID 13564—
Reactant6,7,8,9-Tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamineHCID 57853872—
Productacetic acid 2-(2-amino-6,7-dihydro-9H-5-thia-8-aza-benzocyclohepten-8-yl)-ethyl esterHCID 6726341985.1%

Reaction Steps

Following the procedure of 521a, 6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine (0.28 g, 0.0015 mol) and 2-bromoethyl acetate (0.40 g, 0.0023 mol) were reacted to give acetic acid 2-(2-amino-6,7-dihydro-9H-5-thia-8-aza-benzocyclohepten-8-yl)-ethyl ester (0.34 g, 83%) as an oil. LC/MS (ESI+): 266 (M).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08552186B2
Source datasetuspto-grants-2013_10
ORD IDord-ce06cb56528141d8accf67c1c80372b6
Source noteuspto-grants-2013_10