HCID 67264286, compound → HCID 16744027, compound

HRID 1040955Notes

Reaction equation

HRID 1040955 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:14]([O-])=O)=[C:7]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)[CH:8]=1>[Pd].CCO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:14])=[C:7]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)[CH:8]=1

Participants

4

Reactant 1

HCID 67264286HCID 67264286, compound

Product 1

HCID 16744027HCID 16744027, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(5-Methoxy-2-nitro-phenyl)-1H-pyrazole was treated under standard hydrogenation conditions (H2, EtOH, 10% Pd/C) to yield desired 4-Methoxy-2-pyrazol-1-yl-phenylamine as a crude solid, which was used for the subsequent reaction without further purification; TLC: 1:1 EtOAc/Hexane Rf 0.6, homogeneous; SM Rf 0.7; MS (m/e) 190.12 (M+H).

Sources & evidence

ORD record
ord-d8097fa61bcd43ec8c7407dd31c5f000
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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