HCID 67263924, compound → HCID 67263595, compound

HRID 1040967Notes

Reaction equation

HRID 1040967 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:6][C:5]=1[N:16]1[CH:20]=[CH:19][CH:18]=[N:17]1)([O-])=O>[Pd].CCO>[N:10]1([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[C:5]([N:16]3[CH:20]=[CH:19][CH:18]=[N:17]3)[CH:6]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Participants

4

Reactant 1

HCID 67263924HCID 67263924, compound

Product 1

HCID 67263595HCID 67263595, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(4-Nitro-3-pyrazol-1-yl-phenyl)-morpholine was treated under standard hydrogenation conditions (H2, EtOH, 10% Pd/C) to yield desired 4-Morpholin-4-yl-2-pyrazol-1-yl-phenylamine as a crude oil, which was used for the subsequent reaction without further purification; TLC: 10:1 CH2Cl2:MeOH Rf 0.6, homogeneous (SM Rf 0.7); MS (m/e) 245.17 (M+H).

Sources & evidence

ORD record
ord-cc7ce79f55da44ba999eadb79449df71
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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