HCID 67264335, compound → HCID 67264140, compound

HRID 1040970Notes

Reaction equation

HRID 1040970 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([N:17]3[CH:21]=[CH:20][CH:19]=[N:18]3)[CH:9]=2)[CH2:4][CH2:3]1>[Pd].CCO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[C:10]([N:17]3[CH:21]=[CH:20][CH:19]=[N:18]3)[CH:9]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 67264335HCID 67264335, compound

Product 1

HCID 67264140HCID 67264140, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-Methyl-4-(4-nitro-3-pyrazol-1-yl-phenyl)-piperazine was treated under standard hydrogenation conditions (H2, EtOH, 10% Pd/C) to yield desired 4-(4-Methyl-piperazin-1-yl)-2-pyrazol-1-yl-phenylamine as a crude oil, which was used for the subsequent reaction without further purification; LC/MS (m/e) 258.24 (M+H).

Sources & evidence

ORD record
ord-a6c8765840d3425e85d72cc9b35883e4
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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