HCID 67264430, compound → HCID 67263908, compound

HRID 1040974Notes

Reaction equation

HRID 1040974 reaction equation
[O:1]1[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:14][CH2:13][C:12]2[CH:15]=[C:16]([N+:21]([O-])=O)[C:17]([O:19][CH3:20])=[CH:18][C:11]=2[CH2:10][CH2:9]1>[Pd].CCO>[O:1]1[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:9][CH2:10][C:11]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([NH2:21])=[CH:15][C:12]=2[CH2:13][CH2:14]1

Participants

4

Reactant 1

HCID 67264430HCID 67264430, compound

Product 1

HCID 67263908HCID 67263908, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-1,4-Dioxinan-2-ylmethyl-7-methoxy-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine was treated under standard hydrogenation conditions (H2, EtOH, 10% Pd/C) to yield desired 3-1,4-Dioxinan-2-ylmethyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamine as a crude oil, which was used for the subsequent reaction without further purification; LC/MS (m/e) 293.15 (M+H).

Sources & evidence

ORD record
ord-1a4f463c8f22477b8ce097f0af3873f2
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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