HCID 67263908, compound → HCID 67263908, compound

HRID 1040975Notes

Reaction equation

HRID 1040975 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=2[N:17]2[CH:21]=[CH:20][CH:19]=[N:18]2)[C:5]([Cl:22])=[CH:4][N:3]=1.[O:23]1[CH2:28][CH2:27][O:26][CH2:25][CH:24]1[CH2:29][N:30]1[CH2:36][CH2:35][C:34]2[CH:37]=[C:38]([O:42][CH3:43])[C:39]([NH2:41])=[CH:40][C:33]=2[CH2:32][CH2:31]1>>[Cl:22][C:5]1[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=2[N:17]2[CH:21]=[CH:20][CH:19]=[N:18]2)=[N:7][C:2]([NH:41][C:39]2[C:38]([O:42][CH3:43])=[CH:37][C:34]3[CH2:35][CH2:36][N:30]([CH2:29][CH:24]4[CH2:25][O:26][CH2:27][CH2:28][O:23]4)[CH2:31][CH2:32][C:33]=3[CH:40]=2)=[N:3][CH:4]=1.[O:23]1[CH2:28][CH2:27][O:26][CH2:25][CH:24]1[CH2:29][N:30]1[CH2:36][CH2:35][C:34]2[CH:37]=[C:38]([O:42][CH3:43])[C:39]([NH2:41])=[CH:40][C:33]=2[CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 67263908HCID 67263908, compoundHCID 86633898HCID 86633898, compound

Product 2

HCID 67263908HCID 67263908, compoundHCID 131729559HCID 131729559, compound

Procedure

(2,5-Dichloro-pyrimidin-4-yl)-(4-methoxy-2-pyrazol-1-yl-phenyl)-amine, of Example 611c, was reacted with 3-1,4-Dioxinan-2-ylmethyl-8-methoxy-2,3,4,5-tetra hydro-1H-3-benzazepin-7-ylamine, in a similar manner as Example 601b, to yield desired product 3-1,4-Dioxinan-2-ylmethyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamine as a lyophylate (40%); 1H NMR (400 MHz, DMSO-d6) δ 9.91 (s, 2H), 8.20 (s, 1H), 8.13 (s, 1H), 8.09 (s, 1H), 7.87 (d, J=9.01 Hz, 1H), 7.80 (s, 1H), 7.59 (s, 1H), 7.24 (s, 1H), 6.99 (bs, 1H), 6.93 (s, 1H), 6.52 (s, 1H), 4.06 (m, 1H), 3.88 (s, 3H), 3.80 (s, 3H), 3.7-3.4 (H2O+6H), 3.3-2.9 (m, 9H), 2.67 (m, 1H); MS (m/e) 592.24 (M+H).

Sources & evidence

ORD record
ord-55f6c0892b0f4ee488f09ce5f7691733
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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