2,4,5-Trichloropyrimidine → 2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-benzamide

HRID 1041287Notes

Reaction equation

HRID 1041287 reaction equation
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:12][C:13]1[N:18]=[C:17](Cl)[C:16]([Cl:20])=[CH:15][N:14]=1>>[Cl:12][C:13]1[N:18]=[C:17]([NH:1][C:2]2[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([NH2:6])=[O:5])[C:16]([Cl:20])=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 152567912-Amino-3-fluorobenzamide

Product 1

HCID 866339872-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-benzamide

Procedure

2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-benzamide was prepared from 2-Amino-3-fluoro-benzamide and 2,4,5 Trichloropyrimidine in an analogous manner to Example 1230a. Product was isolated as an off-white solid.

Workup

  1. customProduct was isolated as an off-white solid

Sources & evidence

ORD record
ord-ccc3bb2ea8cc4d598cc530a6a1b24366
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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