HRID1041332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)CC(NC(=O)N2CCCC2)C(=O)Nc2cc(N)ccc21

HCID67263963

未命名化合物

HCID71742191

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)NC(=O)C(NC(=O)N2CCCC2)CC3(C)C)ncc1Cl

HCID57392000

未命名化合物

PROCEDURE

实验过程

Pyrrolidine-1-carboxylic acid {8-[5-chloro-4-(2-fluoro-6-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}-amide was prepared from Pyrrolidine-1-carboxylic acid (8-amino-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)-amide and 2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide in an analogous manner to

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e564afe5273e4de6b2e767562e2d9959
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08552186B2
来源说明: uspto-grants-2013_10

反应 SMILES

[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[C:6]([CH3:21])([CH3:20])[CH2:7][CH:8]([NH:12][C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[C:9](=[O:11])[NH:10][C:4]=2[CH:3]=1.Cl[C:25]1[N:30]=[C:29]([NH:31][C:32]2[C:41]([F:42])=[CH:40][CH:39]=[CH:38][C:33]=2[C:34]([NH:36][CH3:37])=[O:35])[C:28]([Cl:43])=[CH:27][N:26]=1>>[Cl:43][C:28]1[C:29]([NH:31][C:32]2[C:33]([C:34](=[O:35])[NH:36][CH3:37])=[CH:38][CH:39]=[CH:40][C:41]=2[F:42])=[N:30][C:25]([NH:1][C:2]2[CH:23]=[CH:22][C:5]3[C:6]([CH3:20])([CH3:21])[CH2:7][CH:8]([NH:12][C:13]([N:15]4[CH2:19][CH2:18][CH2:17][CH2:16]4)=[O:14])[C:9](=[O:11])[NH:10][C:4]=3[CH:3]=2)=[N:26][CH:27]=1