2,4,5-Trichloropyrimidine → HCID 86634010, compound

HRID 1041340Notes

Reaction equation

HRID 1041340 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[OH:10].[Cl:11][C:12]1[N:17]=[C:16](Cl)[C:15]([Cl:19])=[CH:14][N:13]=1>>[Cl:11][C:12]1[N:17]=[C:16]([O:10][C:3]2[C:4]([O:8][CH3:9])=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:15]([Cl:19])=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 27373672-Fluoro-6-methoxyphenol

Product 1

HCID 86634010HCID 86634010, compound

Procedure

2,5-Dichloro-4-(2-fluoro-6-methoxy-phenoxy)-pyrimidine was prepared from 2-Fluoro-6-methoxy-phenol and 2,4,5-Trichloropyrimidine in an analogous manner to Example 1230a. (1.95 g, 96%) LCMS 290 (M+H), 1H-NMR (DMSO-d6, 400 MHz) δ 8.91 (s, 1H), 7.38-7.34 (m, 1H), 7.10-7.03 (m, 2H), 3.80 (s, 3H).

Sources & evidence

ORD record
ord-1aa8d77b47d64ac5ae0ac2094c047822
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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