HCID 67263949, compound → HCID 66829725, compound

Participants

Reaction Steps

Following an analogous procedure as described in Example 1451, 8-amino-1-ethyl-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one was converted to 8-{5-Chloro-4-[2-(2-morpholin-4-yl-ethoxy)-phenylamino]-pyrimidin-2-ylamino}-1-ethyl-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one TFA salt (78 mg, 56%). 1H-NMR (DMSO-D6, 400 MHz) 6 NMR 9.50 (bs, 1H), 9.40 (s, 1H), 8.45 (s, 1H), 8.16 (s, 1H), 7.87 (d, 1H), 7.38 (d, 1H), 7.30 (t, 1H), 7.20 9d, 1H), 6.85 (t, 1H), 6.80 (bs, 2H), 4.42 (s, 2H), 3.94 (t, 2H), 3.35-3.70 (m, 12H), 3.0-3.25 (m, 2H), 1.07 (t, 3H). LC/MS (ESI+) 558.37 (M+H). MP 223-225° C.

Provenance & Evidence