HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Nitro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 1-Acetyl-8-amino-1,3,4,5-tetrahydro-benzo[b]azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Nitro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 4093214 | — |
| Reactant | 5,5-Dimethyl-8-nitro-4,5-dihydro-1H-benzo[B]azepin-2(3H)-one | HCID 57853853 | — |
| Product | 1-Acetyl-8-amino-1,3,4,5-tetrahydro-benzo[b]azepin-2-one | HCID 67263988 | — |
Reaction Steps
1-Acetyl-8-amino-1,3,4,5-tetrahydro-benzo[b]azepin-2-one was prepared by acylation and reduction of 8-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one (Johnson, Paul D. et al. Bioorganic Med. Chem. Letters 2003, 13, 4197-4200) as described for 5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one (Example N?).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552186B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-a09ed5dece56431490143d3964cddd9f |
| Source note | uspto-grants-2013_10 |